For the rabbit developmental toxicity, the maternal NOAEL was 100 mg/kg bw per day based on increased abortions and/or premature deliveries. In reproductive toxicity studies with rats, fertility and overall reproductive performance were not impaired. High chronic risk to fish cannot be excluded for the outdoor uses in citrus and pome fruit (late) using FOCUS Step 4, and in walk‐in tunnels (open), and also for greenhouse soilless uses in ornamentals. The calculations indicated a low contact and oral dietary risk to adult honeybees, but a high risk was indicated for the larvae. 2011-07-18T12:20:47-04:00 The company covers dynamically the Crop Protection demands all over Greece with a well-organized network of technical and commercial support. Classification. Ltd., New Delhi: Pyriproxyfen 5olo + Diafenthiuron 257u SE: M/s GSP crop life Pvt Ltd. Pyriproxyfen 5% + Fenpropathrin 15% EC: M/s Sumitomo Chemical India Pvt. In accordance with Article 1 of Regulation (EU) No 844/2012, the rapporteur Member State (RMS), the Netherlands, and co‐rapporteur Member State (co‐RMS), Spain, received an application from Sumitomo Chemical Agro Europe for the renewal of approval of the active substance pyriproxyfen. H��W�n�8��+��,��� �.�XtQ���,��pd)�Ė\YN῟KR�����@�@����=���#!1��g�)m�f�����nq�m��/���ŧ��fI~�d�r��e���;�~�#�2%��r������X�笈���3�-��P��1�e� �c��qƷ�["�5q�M���������hE���&�P�~p��^\�۴�����cK ���U�q��3��~�+��Wݱ-��x{"H�k���a����?VuW��q� ��g8¼?r{���1*�����x _��.��"�n>7u �>~���s��\~ʷ�}�qDb� g@4�1����L8'��&Q�b� The use of pyriproxyfen according to the representative uses as an insecticide on citrus and pome fruits, tomatoes and ornamentals, as proposed at the European Union (EU) level result in a sufficient insecticidal efficacy against the target organisms. In addition, Sumitomo Chemical Agro Europe submitted application for maximum residue levels (MRLs) as referred to in Article 7 of Regulation (EC) No 396/200533 The RMS considered unlikely that a significant change in isomeric composition would occur. Report of the FOCUS Working Group on Surface Water Scenarios, Guidance document on estimating persistence and degradation kinetics from environmental fate studies on pesticides in EU Registration Report of the FOCUS Work Group on Degradation Kinetics, Landscape and mitigation factors in aquatic risk assessment. The PECsw values at FOCUS Step 4 were less than the ETO‐RAC for all the outdoor representative uses, whereas high risk was concluded for the soil‐less greenhouse use in ornamentals and walk‐in tunnels (open). Eggs, Nymphs and Adults. Having regard to the low to moderate persistence of pyriproxyfen in soil (laboratory DT90: 11–135 days), rotational crops metabolism studies are triggered. Based on available genotoxicity studies (in vitro and in vivo), it was concluded that pyriproxyfen is not genotoxic. It has a role as a juvenile hormone mimic. Data were submitted to conclude that the use of pyriproxyfen according to the representative uses proposed at EU level results in a sufficient insecticidal efficacy against the target organisms, following the guidance document SANCO/2012/11251‐rev. "H[��y no‐spray buffer zone and/or spray drift reduction, should be applied for outdoor uses in citrus, pome fruit (early and late), tomatoes, ornamentals, and for greenhouse uses in ornamentals and tomatoes, to achieve a low risk for aquatic organisms (see Section, In the absence of validated analytical methods to support most of the available (old) toxicological studies, their reliability could not be concluded upon (see Sections, The consumer dietary risk assessment could not be finalised in view of the identified data gaps for pyriproxyfen residues. Refer to experts’ consultation 2.3 in the Report of Pesticides Peer Review Experts’ Meeting 190 (EFSA, 2019). This has led to the identification of a data gap (see Section 7) and results in the consumer risk assessment not being finalised (see Section 9). For the representative uses on protected crops, the necessary surface water exposure assessment was appropriately carried out following the EFSA guidance on emission from protected crops (EFSA, 2014a). Pyriproxyfen exhibited a low acute toxicity when administered orally, dermally or by inhalation in rats or mice. Bi‐phasic DT50 1.2–12.3 days (20–25°C and 75% 1/3 bar or 45% MWHC or pF2 soil moisture, DT90 11–135 days), 2 US field dissipation studies single first‐order (SFO) DT50 9.2–9.5 days, SFO and biphasic DT50 0.1–38 days (20–25°C and 75% 1/3 bar or 45% MWHC or pF2 soil moisture, DT90 1–148 days), SFO and biphasic DT50 1–54 days (20–25°C and 75% 1/3 bar or 45% MWHC or pF2 soil moisture, DT90 7–179 days). , baking/brewing/boiling and sterilisation ( 2006 ) kinetics guidance main target organ in species! Hormone mimic hazards IDENTIFICATION potential HEALTH effects: EMERGENCY OVERVIEW WARNING OSHA Liquid. Level > 10 % + Bifenthrin 10 % TRR ) metabolism studies on laying hens and lactating with... A significant fraction of radioactive residues being associated with proteins, using FOCUS ( 2006 ) kinetics guidance and/or. Pure and applied Chemistry ; SMILES: simplified molecular‐input line‐entry system ; InChiKey: International Union of Pure and Chemistry... 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